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Updated: Jan 12, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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N6-甲基氨酸阅读器YTHDF3介导的Lcn2mRNA稳定性促进了crizotinib的肝毒性

Ruijuan Liu1,2, Huihui Liu1,2, Haoyang Chen1,2

  • 1Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Toxicological sciences : an official journal of the Society of Toxicology
|November 3, 2025
PubMed
概括

克里佐替尼因通过YTHDF3-LCN2通路诱导亡而导致肝损伤. 对YTHDF3的下调会增加LCN2,促进细胞死亡,为预防crizotinib肝毒性提供标.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.克里佐丁尼布 (crizotinib) 是一种可以药物诱导的肝损伤是药物诱导的利波卡林-2的使用方法这是一种N6-甲基氨酸.

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Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

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