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刺激反应性STING纳米疫苗用于HPV诱导癌症的全身治疗

Shuang Chen1,2, Shuyue Ye1,2, Gang Huang1,2

  • 1Department of Biomedical Engineering, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390.

Proceedings of the National Academy of Sciences of the United States of America
|November 3, 2025
PubMed
概括

一种新型纳米疫苗激活了STING通路,以增强T细胞对人类乳头瘤病毒 (HPV) 诱导的癌症的免疫力. 这种对刺激有反应的设计可以改善抗瘤反应,同时最大限度地降低全身毒性,从而有效治疗癌症.

关键词:
由于HPV引起的癌症.刺信号传递的信号.通过T细胞治疗治疗.纳米颗粒疫苗的使用方法对刺激有反应的纳米粒子.

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