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相关概念视频

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

217
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
217
Drug Therapy01:28

Drug Therapy

237
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
237
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

182
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
182
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

801
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
801
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

245
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
245
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

161
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
161

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相关实验视频

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A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
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痴呆症中的药物偏差:一个范围审查

Shang Liu1, Yan Chen2, Can Wang1

  • 1From School of Nursing, Hunan University of Chinese Medicine and.

Journal of gerontological nursing
|November 3, 2025
PubMed
概括

药物偏差在痴呆症患者 (PWD) 中很常见. 本次审查确定了导致这些偏差的个人,护理人员和药物因素,强调了需要改进管理策略的必要性.

科学领域:

  • 老年学是一门学科.
  • 药理学 药理学是指药理学的学科.
  • 公共卫生 公共卫生

背景情况:

  • 痴呆症患者 (PWD) 经常在药物管理方面扎,导致药物偏差.
  • 这些偏差可能会增加药物不良事件和住院住院的风险.

研究的目的:

  • 确定和总结影响PWD药物偏差的因素.
  • 为改善药物管理策略提供参考资料.

主要方法:

  • 使用了一个范围审查方法.
  • 2015年1月1日至2025年3月1日期间发表的研究在六个数据库中进行文献搜索.
  • 包括调查PWD药物偏差的横截面和队列研究.

主要成果:

  • 审查中包括了21项研究.
  • 常见的评估工具包括酒标准®和STOPP标准.
  • 风险因素被分为个人,护理人员和与药物相关的领域.
  • 潜在不合适的药物是最常见的偏差类型,率从12.2%到85%.

结论:

  • 药物偏差在痴呆症患者中很普遍.

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  • 通过审查,护理人员教育和多学科方法加强药物管理至关重要.
  • 未来的研究应该集中在标准化工具和痴呆症特定策略上.