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相关概念视频

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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基于水凝的眼部药物输送系统.

Farzaneh Sabbagh1, Seyed Shahrooz Zargarian1, Alicja Kosik-Kozioł1

  • 1Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, 02-106 Warsaw, Poland. fsabbagh@ippt.pan.pl.

Journal of materials chemistry. B
|November 3, 2025
PubMed
概括

水凝为眼部药物输送提供了一个有前途的解决方案,克服了生物障碍,提高了药物的生物可用性,并使眼和黄斑变性等疾病的持续释放成为可能.

科学领域:

  • 眼科和生物材料科学 眼科和生物材料科学

背景情况:

  • 由于角膜上皮和视网膜血液屏障,眼部药物输送面临重大挑战,导致药物的生物利用率低 (<5%) 和快速降解.
  • 现有的治疗方法往往无法在眼睛中达到治疗性药物度,因此需要创新的输送系统.

研究的目的:

  • 审查基于水凝的系统在增强药物输送到眼睛前后两部分的潜力.
  • 评估水凝制造方法,表征技术及其在眼科治疗中的应用.

主要方法:

  • 探索水凝的物理化学性质 (胀,风湿学) 和药物释放动力学.
  • 审查水凝制造技术,包括化学交联和3D打印.
  • 对机械稳定性和监管合规性进行表征方法的分析.

主要成果:

  • 水凝表现出受控释放,粘膜粘合和生物相容性,使长时间的眼部药物输送成为可能.
  • 像DEXTENZA®和ReSure®密封剂这样的商业产品展示了在角膜密封和炎症控制中的水凝有效性.
  • 新兴技术包括用于视网膜再生的生物工程水凝,纳米技术集成,以及用于眼的刺激响应系统.

结论:

  • 水凝对最小侵入性眼部治疗具有显著的前景,改善了临床结果和患者的遵守.
  • 解决可扩展性和生产成本方面的挑战对于广泛采用至关重要.

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  • 水凝对于进步治疗青光眼,与年龄相关的黄斑变性和干眼综合征至关重要.