免疫控制疼痛的作用
Léa Paolini1, Johanna Sigaux2, Marie Christophe Boissier2
1Inserm U1125, UFR SMBH, 1, rue de Chablis, 93000 Bobigny, France; Université Sorbonne Paris Nord, Bobigny, France.
Joint bone spine
|November 3, 2025
概括
疼痛是一种复杂的神经免疫疾病,免疫细胞显著影响疼痛感知和分辨率. 了解这些免疫通路为治疗慢性疼痛提供了新的治疗策略,特别是在类风湿性疾病中.
科学领域:
- 神经免疫学 神经免疫学
- 疼痛研究 疼痛研究
- 免疫学 免疫学 免疫学
背景情况:
- 疼痛越来越被认为是一种神经免疫性疾病,涉及免疫细胞和体感系统之间的复杂相互作用.
- 免疫细胞在疼痛的启动,敏感化和解决方面发挥着至关重要的作用.
- 神经免疫通路对于理解疼痛持续性和开发新疗法至关重要.
研究的目的:
- 阐明参与疼痛调节的免疫路径.
- 为了说明免疫细胞和介质对疼痛持久性的贡献.
- 探索针对神经免疫相互作用来治疗疼痛的新兴治疗前景.
主要方法:
- 本综述综合了当前关于先天性和适应性免疫细胞在疼痛中的作用的研究.
- 它检查了外围和中心敏感化的机制,以及免疫感受的概念.
- 该评论讨论了针对免疫系统的各种治疗策略,以解决疼痛.
主要成果:
- 原生和自适应性免疫细胞 (如巨细胞,T细胞,B细胞,中性粒细胞,巨细胞,NK细胞) 通过促炎和抗炎途径调节疼痛.
- 神经免疫相互作用对于疼痛感知至关重要,这是外周/中心敏感化和免疫感知所强调的.
- 向免疫路径,包括细胞因子抑制剂,IL-2,JAK抑制剂,迷走神经刺激和微生物群调节,显示出解决疼痛的希望.
结论:
- 疼痛调节是由复杂的神经免疫相互作用驱动的,其中免疫细胞既起到疼痛触发器和调节器的作用.
- 对这些神经免疫机制的全面理解为慢性疼痛开辟了新的治疗途径.
- 针对免疫路径具有预防和管理慢性疼痛的巨大潜力,特别是在类风湿性疾病中.
相关概念视频
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:44Nociception
33.0K
Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain.
33.0K
01:20Pain
1.2K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.2K
01:28Inflammatory Response
15.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.9K
01:29Blood and Nerve Supply to the Bones
13.5K
Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
13.5K
01:24Local Anesthetics: Differential Sensitivity of Nerve Fibers
1.3K
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
1.3K