从猫 fundus 阅读系统性疾病:多模式大语言模型和兽医临床医生的多中心比较
Emre Eren1, Murat İlgün2, Büşra Kibar3
1Department of Internal Medicine, Faculty of Veterinary Medicine, Atatürk University, Erzurum, Turkey.
Veterinary journal (London, England : 1997)
|November 3, 2025
概括
大型语言模型 (LLM) 显示出近乎专家的诊断性能,用于从骨髓图像中识别猫类系统性疾病. 这些人工智能工具比人类临床医生提供更快的分析,可能提高兽医诊断效率.
科学领域:
- 兽医眼科医生 兽医眼科医生
- 人工智能在诊断中的应用
- 猫科动物医学 猫科动物医学
背景情况:
- 猫的系统性疾病可以表现为 fundus 图像.
- 准确解释这些图像对于及时诊断和治疗至关重要.
- 目前的诊断方法依赖于经验丰富的兽医临床医生.
研究的目的:
- 评估大型语言模型 (LLM) 的诊断性能,以从底部图像中推断猫的系统性疾病.
- 将LLM的诊断能力与兽医临床医生 (专家和新手) 的诊断能力进行比较.
- 评估LLM在提高兽医眼科诊断效率方面的潜力.
主要方法:
- 一项多中心研究,涉及50只猫类病例,带有 fundus 照片和描述符.
- 两个LLM (ChatGPT-5,ChatGPT-5思维) 在纯文本和多模式 (文本和图像) 模式下进行了测试.
- 通过使用诊断分数和准确度指标,LLM的表现与两名专家眼科医生和两名新手临床医生进行了比较.
主要成果:
- 多模式LLM实现了接近专家的诊断性能,Top-1/Top-2/Top-3准确度为34-46%,62-74%和74-86%.
- 与专家临床医生相比,LLM的表现明显优于新手读者 (p < 0.05),并且没有显著差异.
- 与人类 (117-132s) 相比,LLM的反应时间 (13.7-84.6s) 显著缩短.
结论:
- 多模式LLM提供快速,接近专家级的诊断支持,用于猫 fundus 图像解释.
- 整合LLM辅助分析可以提高兽医眼科医学的工作流程效率.
- 在不取代临床医师监督的情况下,LLM有可能提高诊断能力.
相关概念视频
Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Classification of Illness
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe and...
Mouse Models of Cancer Study
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Methods of Documentation VI: Case Management Model
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...
For example, a patient with a chronic illness...
Introduction to Language of Pathophysiology l
Pathophysiology investigates how biological mechanisms—typically starting at the cellular level—disrupt normal bodily functions. It bridges anatomy and physiology to explain the progression of disease. With this foundation, it is important to understand the following key terms used to describe disease processes: Diagnosis:The process of identifying a disease using clinical evaluation, including signs (objective evidence like rashes), symptoms (subjective experiences like pain), laboratory test...
Introduction to Language of Pathophysiology ll
This lesson explores key terms that describe how diseases progress, their outcomes, and their distribution in populations.Diagnostic tests identify diseases and monitor treatment. These include blood and urine tests, biopsies, imaging (X-ray, MRI), and detection of infectious agents.Remission is a reduction or disappearance of symptoms.Exacerbation refers to the worsening of symptoms, such as increased wheezing during an asthma attack.A precipitating factor triggers an acute episode, while a...


