与心血管疾病相关的血蛋白与SCAPIS中的肺功能有关
Suneela Zaigham1, Per Liv2, Elin Chorell2
1Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.
Respiratory medicine
|November 3, 2025
概括
低肺功能与心血管疾病 (CVD) 风险有关. 这项研究发现,包括勒在内的几个与心血管疾病相关的蛋白质与肺功能减弱有关,这表明炎症和新陈代谢起着作用.
科学领域:
- 心血管疾病的研究研究.
- 肺功能研究研究肺功能研究.
- 蛋白质组学和生物标志物发现发现.
背景情况:
- 低肺功能是心血管疾病 (CVD) 的已知危险因素.
- 连接肺功能和心血管疾病的生物机制尚不清楚.
- 研究与心血管疾病相关的血蛋白可能会阐明这些机制.
研究的目的:
- 检查与心血管疾病相关的血蛋白和肺功能测量之间的关联.
- 确定可能调解肺功能与心血管疾病风险之间的关系的特定蛋白质.
主要方法:
- 在瑞典两大人口队列中分析血蛋白质概况 (SCAPIS,n=4,982和试点研究,n=1,054).
- 利用多重线性回归来评估92种心血管疾病相关蛋白和肺功能参数 (FEV1,FVC,FEV1/FVC) 之间的关联.
- 为混因素进行了调整,并应用了Benjaminini-Hochberg校正用于多次测试,在复制队列中进行验证.
主要成果:
- 有相当多的蛋白质与肺功能相关:69个与FEV1相关,57个与FVC相关,9个与FEV1/FVC相关.
- 炎症性蛋白质和阿迪波金,尤其是勒素和介乐金-6,与较低的肺功能有着一致的联系.
- 莱普与FEV1和FVC显示出最强的负相关性.
结论:
- 与心血管疾病相关的蛋白质,特别是那些参与炎症和新陈代谢的蛋白质,与肺功能减弱有关 (FEV1和FVC).
- 研究结果支持系统性炎症,阿迪波金代谢和肺功能受损之间的联系.
- 莱普的强烈关联表明,它可能在肥胖之外发挥作用,因此需要进一步研究生物标志物和治疗潜力.
相关概念视频
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
529
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
529
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
777
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
777
Pulmonary Hypertension: Classification and Pathogenesis
557
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
557
Psychoneuroimmunology: Cardiovascular Disease
379
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
379
COPD: Pathogenesis and Clinical Features
1.7K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.7K
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
3.5K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.5K


