开发一种完全生物基的pH响应纳米复合物,用于针对性地提供5-甲:合成,表征和细胞毒性研究
Hafezeh Nabipour1, Sohrab Rohani1, Kathryn Volkening2
1Department of Chemical and Biochemical Engineering, University of Western Ontario, London, ON N6A 5B9, Canada.
International journal of pharmaceutics
|November 3, 2025
概括
这项研究开发了一种对pH响应的纳米载体,使用一种生物基金属有机框架 (Bio-MOF),涂上酸盐和酸盐,用于控制的5-甲 (5-FU) 输送. 该系统显示了针对性癌症治疗的前景,具有可调节的药物释放和生物相容性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物技术是生物技术.
- 纳米技术纳米技术
背景情况:
- 5-甲 (5-FU) 是一种关键的化疗剂.
- 开发有效的纳米载体对于向癌症治疗至关重要.
- 响应pH的系统可以改善向瘤微环境的药物输送.
研究的目的:
- 设计和合成一个响应pH的纳米载体,用于控制的5-FU输送.
- 为了评估纳米载体的物理化学特性和药物释放行为.
- 评估开发系统的生物相容性和抗癌疗效.
主要方法:
- 一个完全基于生物的金属有机框架 (Bio-MOF) 的合成.
- 将5-FU加载到生物MOF中,然后用酸盐 (CH) 和酸盐 (SA) 涂层.
- 物理化学表征 (FT-IR,SEM,PXRD),胀,生物降解,体外药物释放和细胞毒性测试.
主要成果:
- 成功合成和表征5FU加载的生物MOF (5-FU@Bio-MOF) 和CH/SA涂层的5-FU@Bio-MOF.
- 证明了pH响应的胀和受控的降解,在涂层系统中增强了性能.
- 持续且依赖pH的5-FU释放,在酸性pH (5.5) 时释放量更高,表明瘤向潜力.
- 与正常细胞的高生物相容性和对癌细胞的显著细胞毒性.
- 用CH/SA涂层的5-FU@Bio-MOF显示出更好的控制和生物相容性,而未涂层的5-FU@Bio-MOF则具有更高的抗癌疗效.
结论:
- 生物基MOF系统,特别是生物聚合物涂层,是针对癌症治疗的有效和可持续的纳米载体.
- 开发的纳米载体系统表现出pH响应的药物释放,这对于瘤特异性输送至关重要.
- 对这些功能化纳米载体的进一步研究可以推进可控化疗策略.
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