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Updated: Jan 12, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
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全球监管者DksA作为通过全细胞定向进化识别的纳灵宁生物合成的关键目标

Xuanxuan Zhang1, La Xiang2, Xu Sun3

  • 1Department of Microbial Physiological & Metabolic Engineering, State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

International journal of biological macromolecules
|November 3, 2025
PubMed
概括

全细胞定向进化通过优化全球调节蛋白 (DksA) 和关键酶 (4CL) 来增强原蛋白的产生. 这导致797mg/L的产量,展示了微生物天然产品过度生产的强大策略.

关键词:
生物合成生物合成定向进化是指导进化的.全球监管机构全球监管机构

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Global Regulatory Systems01:28

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Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
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