在慢性疾病中可视化现实世界疼痛治疗途径:在系统性红斑狼中对多药学的基于序列的分析
Nathan Le1, Martha O Kenney2, Andrew Walker3
1Stanford University School of Medicine, Stanford, California.
ACR open rheumatology
|November 3, 2025
概括
系统性红斑狼 (SLE) 的疼痛管理正在从高风险药物转变,但处方强度仍然很高. 多药和治疗模式因年龄和性别而异,突出显示SLE护理中的持续人口差异.
科学领域:
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
- 医疗保健服务研究 医疗服务研究
背景情况:
- 系统性红斑狼 (SLE) 经常涉及慢性疼痛,需要不同的管理策略.
- 了解现实世界疼痛管理模式对于优化SLE患者的治疗结果至关重要.
研究的目的:
- 分析SLE成年人的现实世界疼痛管理趋势.
- 调查疼痛治疗的顺序,多药的流行,以及治疗模式的人口变化.
主要方法:
- 769名患有SLE的成年人的电子健康记录 (EHR) 的回顾性分析 (2005-2024年).
- 利用序列分析和桑基图来绘制治疗轨迹.
- 在两个时间段 (2005-2014年和2015-2024年) 和根据人口因素 (年龄,性别,种族/种族) 进行了疼痛管理模式的比较.
主要成果:
- 葡萄糖皮质类药物和阿片类药物的开始减少;NSAID使用增加.
- 减少了疼痛处方的中位数和多种药物的流行率 (53%至45%).
- 年轻的成年人和男性获得了更多的处方;种族差异缩小了,但在一些分析中仍然存在.
结论:
- 在SLE的疼痛管理正在转向低风险疗法,但处方强度仍然很大.
- 治疗模式和多药在不同的人口群体中表现出显著的差异.
- 可视化提供了宝贵的见解,了解SLE疼痛管理的复杂性和顺序,超出了简单的处方计数.
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