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Updated: Jan 12, 2026

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells
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通过miRNA-374准PGC-1α同时改善β细胞功能障碍并抑制肝脏葡萄糖过度生产

Ji-Won Kim1,2, Joonyub Lee1, Young-Hye You1

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Diabetes & metabolism journal
|November 3, 2025
PubMed
概括

微RNA-374 (miR-374) 通过调节PGC-1α表达,有效降低血糖. 通过改善胰腺小岛功能和减少肝脏胰岛素耐药性,提供miR-374的exendin-4涂层的阴离子脂粒显示出治疗2型糖尿病的前景.

关键词:
糖尿病,第二类糖尿病.葡萄糖的产生和生成.胰岛素分泌的胰岛素分泌.兰格勒汉斯群岛的小岛屿肝脏 肝脏 肝脏 肝脏微RNAs是一种微RNA.

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