中性粒细胞与淋巴细胞比率的增加与精神分裂症患者的症状严重程度有关
Marko Pavlović1,2, Pejana Rastović1,2, Martina Krešić Ćorić1,2
1University Clinical Hospital Mostar.
The journal of medical investigation : JMI
|November 3, 2025
概括
中性粒细胞与淋巴细胞的比率 (NLR) 在精神分裂症患者中较高,与症状严重程度相关. 这种炎症标志物可能表明精神分裂症的疾病状态.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症是一种复杂的精神障碍,其潜在机制受到争论.
- 炎症越来越被认为是精神分裂症发病的潜在因素.
研究的目的:
- 研究中性粒细胞与淋巴细胞比率 (NLR) 与精神分裂症症状严重程度之间的关联.
- 探索NLR与精神分裂症患者的临床/社会人口学变量之间的关系.
主要方法:
- 一项病例对照研究比较了110名精神分裂症患者和110名匹配的健康对照.
- 中性粒细胞与淋巴细胞的比率 (NLR) 是从全血细胞计数计算出来的.
- 使用正负综合征量表 (PANSS) 评估症状严重程度.
主要成果:
- 与对照组相比,精神分裂症患者的中性粒细胞计数和NLR显著增加.
- NLR显示了与PANSS负值,一般精神病理和总分的显著正相关性.
- NLR预测了临床症状,但没有发现与临床/人口统计特征的相关性.
结论:
- 升高的NLR与精神分裂症的症状严重程度增加有关.
- NLR可以作为精神分裂症的状态标志物,反映炎症过程.
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