遗传证据将胃食道逆流症与慢性病和功能衰竭联系起来:一项双步门德尔随机化研究
Fanghong Zheng1,2, Dan Shen1,2, Ying Lv1,2
1Graduate School, Zunyi Medical University, Zunyi, Guizhou, China.
Renal failure
|November 3, 2025
概括
胃食道逆流性疾病 (GERD) 因果上增加了慢性病 (CKD) 的风险. 2型糖尿病和血压调解了这种关联,这表明了预防CKD的干预目标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
- 遗传学 是一个遗传学.
背景情况:
- 胃食道逆流性疾病 (GERD) 很常见,慢性病 (CKD) 是一个日益严重的全球健康问题.
- 潜在的因果关系和GERD和CKD进展之间的调解因素仍然不完全理解.
研究的目的:
- 使用孟德尔随机化研究GERD和CKD进展之间的因果关系.
- 在GERD-CKD路径中识别潜在的代谢媒介,如2型糖尿病 (T2DM) 和静脉血压 (SBP).
主要方法:
- 使用了双样本,双向,双步和多变量门德尔随机化 (MR) 技术.
- 采用了来自GERD全基因组关联研究 (GWAS) 的总结级数据,建议的调解剂,以及来自FinnGen和英国生物银行的CKD (CKD,功能衰竭,透析依赖性功能衰竭) 结果.
- 通过调解剂评估了GERD对CKD进展的直接和间接影响.
主要成果:
- GERD与慢性脏病 (OR: 1.18),功能衰竭 (OR: 1.23) 和透析依赖性功能衰竭 (OR: 1.26) 的风险增加显著相关.
- 从CKD到GERD的逆因果关系没有得到支持.
- 2型糖尿病 (T2DM) 介导了GERD-CKD效应的14.33%-43.24%,其次是静脉压 (SBP) (3.85%-5.46%).
结论:
- GERD对CKD进展具有潜在的因果有害影响.
- T2DM和SBP是从GERD到CKD的因果途径的重要调解者.
- 针对T2DM和SBP可能会减少与GERD相关的CKD负担.
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