通过KDMAge和PhenoAge测量加速生物衰老与消化系统癌症风险之间的关联:使用NHANES数据 (1999-2018) 的跨部门研究 (1999-2018)
Wei Yue Li1, Huan Zhang1, Song Bo Li1
1State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Department of Gastroenterology & Hepatology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Journal of digestive diseases
|November 3, 2025
概括
通过克莱梅拉 - 杜巴尔方法测量年龄 (KDMAge) 和表型年龄 (PhenoAge) 的加速生物衰老与增加消化系统癌症 (DSC) 风险有关. 这些衰老指标显示出新风险评估工具的潜力.
科学领域:
- 老年学是一门学科.
- 在瘤学瘤学.
- 生物统计学 生物统计学
背景情况:
- 消化系统癌症 (DSC) 是全球健康的重大负担.
- 目前,DSC的有效早期检测生物标志物有限.
- 生物衰老指标为风险分层提供了潜在的可能性.
研究的目的:
- 评估生物衰老指数 (KDMAge和PhenoAge) 与DSC风险之间的关联.
- 评估KDMAge和PhenoAge对DSC的预测性能.
- 探索加速衰老与DSC发病率之间的关系.
主要方法:
- 使用了国家健康和营养检查调查 (NHANES) 数据集 (1999-2018).
- 用回归余值计算KDMAge和PhenoAge的生物年龄加速.
- 采用加权后勤回归,限制立方线和倾向得分匹配进行分析.
主要成果:
- KDMAge加速显示出与DSC风险 (OR 1.59) 有显著的正线性关联.
- PhenoAge加速表现出与DSC风险的U形非线性关系.
- 无论是KDMAge还是PhenoAge都表现出中度的预测准确性 (AUROC ~ 0.68).
结论:
- 通过KDMAge和PhenoAge加速的生物衰老与DSC风险显著相关.
- 这些衰老指数可能有助于开发新的DSC风险评估工具.
- 进一步的研究是有必要的,以探索干预策略,以减轻DSC风险.
相关概念视频
01:19Psychoneuroimmunology: Diabetes and Cancer
427
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
427
02:59Cancer Prevention
7.6K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.6K
01:26Aging
578
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
578
01:21Cancer Survival Analysis
639
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
639
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
182
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
182
02:20Longitudinal Research
13.1K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.1K