在炎症性肠病中,口腔肠轴的研究进展
Yi Wei Zhang1,2, Ling Jiao Gong1, Fei Liao1,3
1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
口腔-肠轴,涉及口腔和肠道之间的微生物交叉声,越来越多地与炎症性肠病 (IBD) 的发展有关. 本综述探讨了这种联系如何对IBD病原发生有所贡献.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 全球炎症性肠病 (IBD) 的流行率正在上升.
- 肠道失调被认为是IBD病因学的关键因素.
- 新出现的证据强调了口腔和肠道微生物群之间的联系.
研究的目的:
- 对口腔肠轴的当前研究进行审查.
- 检查口腔肠轴与IBD之间的关系.
- 评估口腔肠轴在IBD病变发生过程中的作用.
主要方法:
- 现有研究的文献综述.
- 分析微生物从口腔到肠道环境的转移.
- 对IBD发展的机制性见解的综合.
主要成果:
- 口腔-肠轴涉及口腔和肠道生态系统之间的微生物交叉.
- 口腔微生物群可以通过血液或肠道途径转移到肠道.
- 这一轴为IBD病原体提供了新的见解.
结论:
- 口腔肠轴在炎症性肠病的发展中起着重要作用.
- 了解这一轴为IBD研究和潜在的治疗策略提供了新的途径.
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