在宿舍患者的精神衰弱治疗中使用psilocybin辅助治疗:可行性,安全性和初步疗效
Yvan Beaussant1,2, Zachary Sager3,2, Caitlin Brennan4,5
1Department of Supportive Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA yvan_beaussant@dfci.harvard.edu.
BMJ supportive & palliative care
|November 3, 2025
概括
松素辅助疗法 (PAT) 显示,它有望减少临终病患者在临终关怀中的丧. 这项试点研究发现PAT是可行的和安全的,并显著改善了患者的福祉.
科学领域:
- 抚慰性护理是一种缓解性护理.
- 心理药理学 心理药理学
- 心理健康 心理健康
背景情况:
- 丧气是临终病患者在宿舍护理中的一个重大问题.
- 目前对这种人群的抑郁症的治疗选择有限.
- 松素辅助疗法 (PAT) 是一种新兴的治疗方式,具有潜在的心理益处.
研究的目的:
- 评估PAT治疗绝症患者精神衰弱的可行性,安全性和初步疗效.
- 评估患者招募,留住和接受PAT在宿舍环境中的情况.
- 测量PAT后的士气降低得分和其他心理社会指标的变化.
主要方法:
- 一个开放的试验试验,涉及10名接受家庭临终关怀的绝症患者.
- 患者接受了准备课程,在住院医院接受一次25毫克西洛西宾课程和整合课程.
- 通过招聘/保留评估可行性;通过不良事件评估安全性;通过丧评分评估有效性.
主要成果:
- PAT耐受性很好,没有严重的西相关不良事件.
- 在第3周观察到丧得分的显著降低 (p=0.0196).
- 悲伤和和平是主要的主题;治疗的可接受性各不相同,可能是由于情绪强度.
结论:
- PAT可以可行且安全地整合到终身临终关怀中.
- 最初的证据表明,PAT可能会减轻绝症患者的丧.
- 需要进一步的研究来优化PAT输送并确认其治疗潜力.
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