肝纤维化与男性的医疗保健症状有关,特别是勃起功能障碍和下泌尿道症状
Yuka Uesaka1, Akira Tsujimura2, Riho Kasai1
1Department of Urology, Juntendo University Urayasu Hospital, Urayasu, Japan.
Investigative and clinical urology
|November 3, 2025
概括
这项研究发现,较高的纤维化-4 (FIB-4) 指数,表明肝纤维化,与男性性功能较差和下泌尿道症状有关. 肝脏健康对男性整体健康很重要.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 内分泌学 在内分泌学.
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝脏功能障碍在男性中正在增加.
- 纤维化-4 (FIB-4) 指数是评估肝纤维化的关键非侵入性工具.
- 了解肝脏健康与男性特异性健康参数之间的联系至关重要.
研究的目的:
- 通过FIB-4指数测量肝纤维化与各种男性健康参数之间的关联.
- 探索肝纤维化与性功能,下泌尿道症状 (LUTS) 和男性荷尔蒙水平之间的关系.
主要方法:
- 使用了国际前列腺症状评分 (IPSS),男性性健康清单 (SHIM),勃起硬度评分 (EHS) 和老年男性症状 (AMS) 尺度的问卷.
- 评估的内分泌学标志物:脱二三酸盐 (DHEA-S),胰岛素样生长因子1 (IGF-1),总和皮质醇.
- 评估的代谢因子:血红蛋白A1c (HbA1c) 和甘油三作为潜在的混因子.
主要成果:
- 更高的FIB-4指数五分位数与性功能下降和LUTS增加相关.
- DHEA-S和IGF-1水平下降,而皮质醇水平随着FIB-4指数的上升而增加.
- 在FIB-4指数和水平之间没有发现显著的关联;HbA1c增加,但甘油三并不相关.
结论:
- 肝纤维化评估对于经历勃起功能障碍和LUTS的男性来说很重要.
- 研究结果支持一种多学科的方法来管理男性健康问题,整合肝功能评估.
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