对药物类型的综合系统性审查,这些药物类型的目标是减记工具以及对每个类别应用的工具/干预措施
Faisal Madanat1,2, Solafa Noorsaeed1,3, Rahaf Alkhlaifat1,2
1Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, UK.
Expert review of clinical pharmacology
|November 3, 2025
概括
本综述确定了针对抑郁症的关键药物以及用于指导这一过程的工具. 它强调需要个性化策略来增强患者安全和改善药物治疗结果.
科学领域:
- 老年人药理学 老年人药理学
- 基于证据的医学基于证据的医学.
- 临床药房 临床药房
背景情况:
- 多药和潜在不合适的药物 (PIMs) 是对患者不良健康结果的重要贡献者.
- 放弃,监督停止PIM,是缓解这些风险的关键策略.
- 识别特定的PIM和有效的减记工具对于临床实践至关重要.
研究的目的:
- 系统地确定现有的抑郁症处方工具所针对的药物类别.
- 根据使用的类型和频率对这些工具进行分层.
- 评估药物特定抑郁症处方工具的可用性和范围.
主要方法:
- 从2010年到2023年,在Embase,PubMed,Scopus和Medline进行了系统的文献搜索.
- 通过使用纽卡斯尔-太华尺度 (NOS) 和修订后的柯克莱恩偏差风险工具 (RoB 2) 评估研究的质量.
- 已识别的药物类别和降低处方工具被总结成一个全面的清单.
主要成果:
- 该审查在82项研究中确定了44种抑郁症工具,针对77种不同的药物类别.
- 最常被准的PIM包括奔类药物,抗精神病药物,α受体阻断剂,质子抑制剂和Z催眠药.
- 广泛使用的抑郁症工具是老年人处方查工具 (STOPP) 脆弱,美国老年病学学会 (AGS) 酒标准,STOPP标准和STOPPFall. 还注意到了特定于药物的工具.
结论:
- 这一系统性审查成功地确定了最常见的向药物类别和主要的抑郁症处方工具.
- 这些发现强调了在抑郁症处方中采用药物特异性和以患者为中心的方法的重要性.
- 实施这些量身定制的策略对于提高患者安全和优化药物相关结果至关重要.
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