来自47个国家的城市废水中的抗生素耐药性选择和取消选择
Zhuofeng Yu1,2, Declan A Gray1,2,3, Jerker Fick4
1Centre for Antibiotic Resistance Research (CARe) at the University of Gothenburg, Gothenburg, Sweden.
Nature communications
|November 3, 2025
概括
市政废水很少选择抗生素耐药性,通常选择反对它. 这项研究调查了驱动因素,发现抗生素选择的证据有限,生物制剂的作用不清楚,表明复杂的混合效应.
科学领域:
- 环境微生物学环境微生物学
- 抗生素耐药性的演变 抗生素耐药性的演变
- 污水处理 污水处理 污水处理
背景情况:
- 废水是抗生素耐药性 (AR) 进化的潜在热点.
- 市政废水对AR选择的经验证据很少.
- 了解选择驱动因素对于公共卫生至关重要.
研究的目的:
- 在全球范围内对未经处理的城市废水进行AR选择进行实验性评估.
- 确定抗生素耐药性选择或取消选择的潜在驱动因素.
- 描述废水中的抗生素和生物制剂度.
主要方法:
- 使用340个混合大肠杆菌菌株的功能选择试验.
- 无菌过和天然废水社区进行了测试.
- 对抗生素和杀菌剂进行全面的化学分析.
主要成果:
- 47个国家中的14个国家的废水显著选择了AR;大多数选择反对它.
- 没有单一的抗生素被确定为大肠杆菌耐药性的关键驱动因素.
- 叶酸抗剂和化物超过了对其他细菌的非选择性度.
- 抗菌生物制剂的共同选择潜力仍然不清楚.
- 化学成分与观察到的选择有很弱的相关性.
结论:
- 大多数城市废水不会对大肠杆菌的抗生素耐药性进行选择.
- 当健身成本超过选择压力时,抗生素耐药性基因可能会丢失.
- 复杂的化学混合物,而不是单个化合物,可能会影响AR动态.
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