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Updated: Jan 12, 2026

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基于VHL的无形SMARCA2 PROTAC的关键功能结构的确定

Daria Torodii1, Jacob B Holmes1,2, Manuel Cordova1,2

  • 1Institut des Sciences et Ingénierie Chimiques, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.

Nature communications
|November 3, 2025
PubMed
概括

针对蛋白质溶解的嵌合体 (PROTACs) 是一种新的治疗方法. 这项研究揭示了SMARCA2 PROTAC的无形结构,发现灵活性,而不是键,稳定了其固体形式,为无法使用的目标提供了洞察力.

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