运动和痴呆风险期间的心率反应和恢复:英国前性生物库研究
Yiran Wei1,2, Yonglin Shan3, Wenxiao Fan1,2
1Department of Neurology, Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, Shandong, P R China.
Scientific reports
|November 3, 2025
概括
更高的心率响应/恢复 (HRR) 指数和恢复比率与更低的痴呆风险有关. 这些心血管健康指标也可能有助于延迟老年人的认知衰退.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 心率响应/恢复 (HRR) 指数是运动期间心血管健康指标.
- 以前的研究将HRR指数与死亡率和神经认知障碍联系起来.
- HRR指数和痴呆风险之间的关联以前是未知的.
研究的目的:
- 研究HRR指数与所有原因痴呆症,阿尔茨海默病 (AD) 和血管痴呆症 (VaD) 的风险之间的关系.
- 检查HRR指数与处理速度,推理和记忆的认知下降之间的相关性.
主要方法:
- 从46,348名英国生物库参与者 (中年和老年人) 的心电图数据分析.
- 标准化亚最大运动压力测试 (15秒的基线,6分钟的运动,1分钟的恢复).
- 计算HRR指数和恢复率;在12.62年的中位数随访期间确定痴呆症诊断.
主要成果:
- 较高的HRR指数和恢复率与所有原因痴呆的风险显著降低有关 (HR:分别为0.72和0.75).
- 没有发现HRR指数/恢复比和事件AD或VaD之间有显著的关联.
- 较高的HRR指数与处理速度,推理和记忆的较慢下降相关;恢复率与推理和记忆的较慢下降相关.
结论:
- 较高的HRR指数和恢复率与痴呆症风险降低有关,并可能延迟认知能力下降.
- 潜在的机制包括自主功能和神经血管健康.
- HRR指数是老年人群认知健康的潜在生物标志物.
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