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牙周病原体Fusobacterium nucleatum与多发性硬化症的疾病严重程度有关

Hiroyuki Naito¹, Masahiro Nakamori^2,3, Hiromi Nishi⁴

¹Department of Clinical Neuroscience and Therapeutics, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8551, Japan.

Scientific reports

|November 3, 2025

概括

口腔细菌Fusobacterium nucleatum可能与多发性硬化症 (MS) 的严重程度增加有关. 这项研究发现,这种病原体的较高丰度与MS患者的临床结果较差相关.

科学领域:

神经免疫学神经免疫学
口腔微生物学口腔微生物学
炎症性疾病炎症性疾病

背景情况:

牙周炎与慢性炎症和中枢神经系统疾病有关.
口腔病原体在多发性硬化症 (MS) 中的特定作用尚不清楚.

研究的目的:

调查口腔微生物群中的牙周病原体与MS临床特征之间的关联.
探索口腔细菌与MS患者疾病严重程度之间的关系.

主要方法:

对98名患有多发性硬化和相关疾病的患者进行了横截面研究.
对四种牙周动物的舌头涂层样本进行定量PCR分析.
病原体丰富度与临床/MRI特征之间的相关性分析,包括扩展残疾状态量表 (EDSS).

主要成果:

高相对丰富的Fusobacterium核素与MS患者的EDSS得分更高显著相关 (p=0.009).
对于其他测试的病原体或非多发性硬化症组中没有发现显著的关联.
多变量分析证实了Fusobacterium nucleatum丰富度作为MS疾病严重程度的独立预测因素.

结论:

在口腔中丰富的fusobacterium nucleatum可能与多发性硬化症的疾病严重程度增加有关.
需要进一步的研究来阐明将这种口腔病原体与MS进展联系在一起的机制.

关键词:

疾病严重程度疾病严重程度扩展的残疾状况尺度扩展残疾状况尺度.杆菌核酸 (Fusobacterium nucleatum) 是一种细菌.多发性硬化症是多发性硬化症.牙周病原体的病原体

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