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预炎性骨髓和中性粒细胞激活与多发性骨髓瘤中TIGIT表达有关

Valeria Tomarchio¹, Francesca Arciprete², Monica Di Cecca¹

¹Hematology, stem cell transplantation, Fondazione Policlinico Universitario Campus Bio medico, Rome, Italy.

Annals of hematology

|November 3, 2025

概括

多发性骨髓瘤骨髓中的TIGIT表达与晚期疾病和炎症环境相关. 这种免疫检查点可以作为一种生物标志物和治疗瘤的治疗标.

科学领域:

血液瘤学血液瘤学
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

多发性骨髓瘤 (MM) 是一种普遍存在的成人血液性恶性瘤.
骨髓微环境对MM进展至关重要,支持癌细胞存活和免疫逃避.
TIGIT是一种新兴的免疫检查点分子,可以抑制抗瘤免疫反应.

研究的目的:

为了研究新诊断的MM患者骨髓中的TIGIT表达.
为了将TIGIT表达与MM疾病特征和微环境特征相关联.
探索TIGIT在MM免疫抑制和炎症的背景下的作用.

主要方法:

来自25名新诊断MM患者的骨髓样本的分析.
免疫组织化学和共聚焦显微镜评估TIGIT表达,免疫细胞定位和中性粒细胞细胞外陷 (NET) 的形成.
TIGIT状态与临床参数,分期 (ISS,R-ISS),细胞遗传学和细胞因子水平 (IL-6,IL-8) 的相关性.

主要成果:

在86%的可评估MM样本中表达了TIGIT.
TIGIT阳性与先进的R-ISS阶段,高风险细胞遗传学和升高的LDH显著相关.
阳性TIGIT样本显示NETosis增加和IL-6和IL-8的升高,这表明一种促炎微环境.

结论:

在MM骨髓中,TIGIT的表达与侵袭性疾病特征有关.
具有形成NET的中性粒细胞的炎症性微环境是TIGIT阳性MM的特征.
TIGIT代表了MM严重程度的潜在生物标志物和治疗点.

关键词:

它们的IL-8和IL-8是不同的.对于Ly6b来说,这是一个很好的方法.在 MM MM MM MM 里面.网络网络网络网络网络这是一个紧张的紧张.

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