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在癌症中的线粒体核糖体RNA基因的功能主导热点突变

Sonia Boscenco1,2, Jacqueline Tait-Mulder3, Minsoo Kim1

  • 1Computational Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature genetics
|November 3, 2025
PubMed
概括

研究人员在癌症基因组中发现了线粒体核糖体RNA (mt-rRNA) 基因在线粒体DNA (mtDNA) 内的反复突变. 这些突变会影响线粒体的功能和翻译,这表明它们是致病的,并且在癌症中被选择.

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