基于各种计算机断层扫描指数的基础上,开发和验证一种预后模型,用于在接受永久性结肠切除术的患者中预测半体的发生
Yayan Fu1, Yifan Cheng2, Chenkai Zhang1
1Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, Jiangsu, China.
Surgical endoscopy
|November 3, 2025
概括
一种新的诺米图准确地预测了直肠切割术后直肠癌患者的半体 (PSH) 风险. 该工具帮助临床医生为高风险人群提供个性化管理和生活方式指导,改善生活质量.
科学领域:
- 在瘤学瘤学.
- 手术并发症 手术并发症
- 医学成像和诊断 医学成像和诊断
背景情况:
- 副直肠 (PSH) 是直肠切除和结肠直肠切除后的常见并发症,影响患者的生活质量.
- 目前的方法在预测PSH发生方面缺乏准确性.
- 准确的预测工具是有效的患者管理所需的.
研究的目的:
- 开发和验证在接受直肠癌永久性结肠切除术的患者中对半直肠 (PSH) 的预测性诺米克图.
- 确定与PSH发展相关的关键风险因素.
- 为临床医生提供一个工具来评估个体PSH风险.
主要方法:
- 对430名因直肠癌而接受永久性结肠直肠切除术的患者进行了回顾性分析.
- 对于因素选择的最小绝对收缩和选择运营商 (LASSO) 分析.
- 多变量逻辑回归和名ogram构造.
- 使用接收器操作特征 (ROC) 曲线,校准图和决策曲线分析 (DCA) 进行验证.
主要成果:
- 该研究确定了PSH的七个显著预测因素:晚年,女性性别,更高的BMI,增加的内脏和皮下脂肪区域,更大的半体脂肪组织和更大的腹壁缺陷.
- 开发的诺米图表表现出良好的预测性能,ROC曲线下的面积在训练集中为0.826,在验证集中为0.867.
- 校准图表证实了预测和观察到的PSH发生之间的强烈一致,DCA强调了名图的临床实用性.
结论:
- 一个经过验证的名谱有效地预测了直肠癌患者在结肠术后的PSH风险.
- 该工具帮助临床医生识别高风险患者,以制定个性化管理策略.
- 诺米图支持生活方式指导,以潜在地减轻PSH的发展,提高患者的生活质量.
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