帕拉姆 (Pathways to Resilience And Mental health) 项目:印度多个地点发展队列的协议
Bharath Holla1, Eesha Sharma2, Shradha Venkataramanan3
1Department of Integrative Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, India.
BMC psychiatry
|November 3, 2025
概括
在印度,Pathways to Resilience And Mental health (PARAM) 项目追踪了从怀孕到30岁的神经发育. 它旨在确定影响心理健康轨迹的因素,以获得更好的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 精神疾病越来越多地通过神经发育的镜头来看待,强调基因与环境的相互作用.
- 了解发育轨迹对于识别脆弱性和对心理病理的性至关重要.
- 需要进行纵向研究来绘制这些途径和相关的风险/保护因素在整个生命周期.
研究的目的:
- 在印度建立一个大规模的多站点纵向队列 (PARAM项目),研究神经发育途径.
- 研究遗传责任和环境暴露的相互作用,从产前期到成年早期.
- 确定可修改的心理健康风险和保护因素,并为精确干预提供信息.
主要方法:
- 该PAthways to Resilience And Mental health (PARAM) 项目招募了约9000名从产前到30岁的参与者,扩大了cVEDA队列.
- 使用重复评估,包括问卷,环境暴露数据,详细检查 (神经成像,神经认知) 和生物样本收集.
- 采用先进的统计分析 (混合效应模型,预测建模) 和八个印度站点的数据协调.
主要成果:
- 帕拉姆正在建立一个关于不同人群中神经发育轨迹的综合数据集.
- 目前正在进行初步分析,以绘制发育路径和相关因素的地图.
- 该项目旨在深入了解基于人口的心理健康趋势.
结论:
- 帕拉姆将提供对基于人口的发展轨迹的关键见解,并确定可修改的风险/保护因素.
- 结果将支持心理病理学预测模型的开发.
- 该项目旨在为全球心理健康研究中的精确干预和公共卫生战略提供信息.
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