风湿性关节炎和心血管疾病协会在英国生物银行
Janek Salatzki1,2, Dorina-Gabriela Condurache1,3, Stefania D'Angelo4
1William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
BMC medicine
|November 4, 2025
概括
风湿性关节炎 (RA) 患者面临各种心血管疾病 (CVD) 的风险增加,包括心脏病发作和心律失常. 有证据表明,RA与这些疾病之间存在潜在的因果关系,独立于其他风险因素.
科学领域:
- 心血管健康的心血管健康
- 类风湿病学 类风湿病学
- 遗传流行病学遗传流行病学
背景情况:
- 类风湿性关节炎 (RA) 是一种自身免疫性疾病,已知与心血管疾病 (CVD) 有关.
- 了解这种关系的确切性质和因果关系对于患者管理至关重要.
研究的目的:
- 调查类风湿关节炎 (RA) 和心血管疾病 (CVD) 之间的观察和因果关系.
- 探索RA和心脏成像表型之间的潜在联系.
主要方法:
- 利用英国生物库数据,通过医院记录,自我报告和药物定义RA.
- 使用后勤和考克斯回归评估了RA和流行/发病心血管疾病之间的关联.
- 采用双样本门德尔随机化推断因果关系,分析RA,心血管疾病和心磁共振 (CMR) 现型的遗传数据.
主要成果:
- 关节炎病例 (1,436) 和对照 (476,975) 显示,关节炎患者患心血管疾病的风险较高,特别是心周病,心力衰竭和急性心肌梗塞 (AMI).
- 门德尔的随机化支持了RA和AMI,心律失常和缺血性心脏病 (IHD) 之间的因果关系.
- 在RA和心磁共振 (CMR) 影像指标之间没有发现显著的关联.
结论:
- 患有类风湿性关节炎 (RA) 的人具有多种流行和发病心血管疾病 (CVD) 的风险.
- 这些增加的风险持续不依赖于共同的风险因素,有证据表明缺血性心脏病 (IHD),急性心肌梗塞 (AMI) 和心律失常的因果途径.
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