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中性细胞细胞外陷调节LDHA表达,促进结直肠癌肝脏转移

Nana Li¹, Shifeng Yang¹, Congxue Hu²

¹Department of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin, 150001, Heilongjiang, China.

Journal of translational medicine

|November 4, 2025

概括

中性粒细胞外细胞陷 (NETs) 通过增加LDHA表达和促进细胞入侵来驱动结直肠癌 (CRC) 肝转移. 抑制LDHA或NET形成会阻止这种进展,为CRC提供新的治疗点.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

转移是结直肠癌 (CRC) 死亡率的主要原因之一.
中性细胞外细胞陷 (NETs) 参与促进瘤进展和转移.

研究的目的:

调查NETs在结直肠癌肝脏转移中的作用.
阐明NETs促进CRC肝转移的潜在分子机制.

主要方法:

对单细胞转录组测序数据库 (scRNA-Seq) 的分析.
在体外实验中使用CRC细胞进行实验.
裸露的老鼠肝异种移植模型.
评估表皮层-介质酶转换 (EMT) 标记物.
细胞对细胞通信的分析.
对PI3K/AKT通路和LDHA表达的研究.

主要成果:

转移性CRC病变中NETs标志物表达升高,与晚期瘤等级相关.
在体外,NETs通过诱导EMT来增强CRC细胞的增殖,迁移和入侵.
网通过PI3K/AKT通路调节LDHA表达,促进CRC细胞的入侵和迁移.
抑制LDHA或NET形成显著减少NET诱导的肝转移.

结论:

NET在促进结直肠癌肝脏转移方面发挥着至关重要的作用.
NETs通过调节LDHA表达并诱导EMT来促进CRC转移.
向LDHA或NET形成是抑制CRC肝转移的潜在治疗策略.

关键词:

结肠直肠癌是一种癌症.乳酸盐是一种乳酸盐.转移转移转移转移中性细胞细胞外陷这就是 scRNA-Seqq.

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lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...