瘤芽预测淋巴结转移在唇部状细胞癌的淋巴结转移
S Leypold1, J Riese1, C Cacchi1
1Institute of Pathology, School of Medicine, University Hospital RWTH Aachen, Pauwelsstrasse 30, Aachen, 52074, Germany.
Head & face medicine
|November 4, 2025
概括
周围瘤的芽是唇状细胞癌 (LSCC) 淋巴结转移的关键预测因素. 这一发现有助于决定LSCC患者的选择性部剖析.
科学领域:
- 在瘤学瘤学.
- 头部和部手术 头部和部手术
- 病理学 病理学 病理学
背景情况:
- 唇状细胞癌 (LSCC) 是一种罕见的癌症.
- 在LSCC中预测淋巴结转移 (LNM) 是具有挑战性的.
- 在LSCC中缺乏选择性部剖析的明确标准.
研究的目的:
- 在LSCC中确定LNM的风险因素.
- 指导选择性部剖析的决策过程.
主要方法:
- 通过81个临床和病理参数评估了57名LSCC患者.
- 使用LASSO进行单变量和多变量逻辑回归进行分析.
- 评估了三种已建立的病理学分级系统.
主要成果:
- 周周瘤芽和瘤大小是LNM的独立预测因素.
- 更高的周围瘤芽与淋巴结阳性状态显著相关 (p < 0.01).
- 与其他系统相比,周围瘤芽显示出更高的预测准确性 (AUC = 0.86).
结论:
- 周围瘤的芽是LSCC中LNM的强有力的预测因素.
- 这一发现可以为部解剖的术前评估提供信息.
- 在LSCC管理中增强选择性部剖析的决策.
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