慢性炎症和胰岛素抵抗对中风的联合影响:一项队列研究和调解分析
Yu Gao1, Zhiping Duan2, Jing Li1
1Internal Medicine Department for Officials, The First Affiliated Hospital of Kunming Medical University, No.295 Xichang Road, Kunming, 650032, Yunnan Province, China.
European journal of medical research
|November 4, 2025
概括
慢性炎症和胰岛素抵抗 (IR) 独立地增加中风风险. 它们的综合作用显著提高了风险,每个条件也介导了另一个条件.
科学领域:
- 公共卫生 公共卫生
- 心血管研究研究心血管研究
- 代谢综合征是代谢综合征的一种.
背景情况:
- 脑卒中对全球的健康构成重大负担.
- 研究慢性炎症和胰岛素抵抗 (IR) 对中风发病率的协同影响至关重要.
- 这项研究使用高灵敏度C反应蛋白 (hsCRP) 和胰岛素抵抗代谢得分 (MetS-IR) 作为生物标志物.
研究的目的:
- 检查慢性炎症和IR对新发性中风风险的独立和联合影响.
- 探索慢性炎症和IR在中风发展中的调解作用.
- 评估hsCRP和MetS-IR在识别高风险中风的个体中的实用性.
主要方法:
- 利用了来自2011年中国健康与退休纵向研究队列的7422名中国成年人 (≥40岁) 没有先前中风的数据.
- 使用禁食葡萄糖,甘油三,BMI和HDL胆固醇水平计算了MetS-IR.
- 采用Cox比例风险建模和调解分析来评估与hsCRP和MetS-IR水平相关的中风风险,在8.6年的随访期间.
主要成果:
- 在随访期间,共有781名参与者 (10.5%) 经历了新的中风.
- 慢性炎症升高 (hsCRP > 1 mg/L) 增加了中风风险64% (HR 1.64),而升高的IR (MetS-IR > 34.4) 增加了风险51% (HR 1.51).
- 患有高慢性炎症和高IR的参与者有95%的中风风险增加 (HR1.95),在炎症和IR之间观察到显著的双向调解.
结论:
- 慢性炎症和IR对中风风险产生独立和相互作用的影响.
- 这些情况表明,在中风的发展中相互调解.
- hsCRP和MetS-IR为评估初级保健和公共卫生机构中风风险提供了一种实用的方法.
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