评估系统性红斑狼患者的认知功能
Juliana Rosa Pires Vieira1, Andrea Toledo de Oliveira Rezende2, Danilo Rocha Dias3
1Scrictu Senso, Program in Health Sciences, School of Medicine, FMUFG, Goiânia, Goiás, Brasil. jurpvieira@yahoo.com.br.
Advances in rheumatology (London, England)
|November 4, 2025
概括
系统性红斑狼 (SLE) 患者经历轻微的认知障碍,影响日常生活. 这些神经认知变化在活跃的SLE和缓解阶段都被观察到,影响了注意力,记忆力和执行功能.
科学领域:
- 类风湿病学 类风湿病学
- 神经心理学 神经心理学
- 临床医学 临床医学
背景情况:
- 神经认知变化显著影响系统性红斑狼 (SLE) 患者的自主性和独立性.
- 这些认知缺陷被认为是SLE管理的主要负面结果.
- 了解这些变化对于改善患者的生活质量至关重要.
研究的目的:
- 评估被诊断患有活跃系统性红斑狼 (SLE) 的患者的认知功能.
- 评估SLE缓解期患者的认知功能.
- 为了比较活跃的SLE和缓解组之间的认知表现.
主要方法:
- 进行了一项横截面研究,采用83名患者的非概率,连续样本.
- 认知功能使用迷你精神状态检查 (MMSE),五位数测试 (FDT) 和雷斯复杂数字 (FCR) 进行评估.
- 排除标准包括抑郁症和酒精或其他药物的使用.
主要成果:
- 在注意力,记忆力,语言和执行功能方面观察到轻微障碍.
- 在SLE活跃患者和缓解期患者 (p > 0.05) 之间注意到认知表现的显著差异.
- 认知功能与SLE诊断的持续时间无关.
结论:
- 认知功能障碍存在于SLE活跃患者和缓解期患者中.
- 这项研究证实,在被诊断患有SLE的患者中,轻度认知障碍.
- 这些发现凸显了对SLE患者认知健康的监测和管理的需要.
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