睡眠时间,选择的循环生物标志物,以及结直肠癌风险
Marta Rossi1, Alessia Pauletto1, Silvia Mignozzi1
1Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, University of Milan, Milan.
概括
较长的睡眠时间,特别是9个小时或更长的睡眠时间,与增加结直肠癌 (CRC) 风险有关. 这种关联可能涉及炎症,代谢变化和肠道屏障问题,这表明睡眠习惯和CRC发展之间存在复杂的关系.
科学领域:
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
- 胃肠病学 胃肠病学
背景情况:
- 睡眠时间是影响结肠直肠癌 (CRC) 风险的潜在因素.
- 机制可能包括炎症,代谢功能障碍和肠道透性.
研究的目的:
- 为了调查睡眠时间和CRC风险之间的关联.
- 探索睡眠时间与炎症,代谢和肠道透性标志物之间的相关性.
主要方法:
- 一项涉及212名参与者的病例控制研究 (71例CRC病例,141例对照).
- 通过问卷评估睡眠习惯;测量血清C反应蛋白 (CRP),血糖,脂多糖结合蛋白,佐努林和细菌16S rRNA基因拷贝.
- 用于根据睡眠时间计算CRC风险的几率比率 (OR) 的后勤回归模型.
主要成果:
- 长时间睡眠 (≥9小时) 和CRC风险 (OR:3.36,95%CI:1.08-10.53) 与7-8小时之间观察到积极的关联.
- 睡眠时间短 (≤6小时) 显示不显著的风险增加 (OR: 1.62,95% CI: 0.84-3.29).
- 较高的BMI,CRP,血糖和特定的链球菌物种在睡眠时间较长的个体中被注意到.
结论:
- 长时间的睡眠时间与患结直肠癌的风险增加有关.
- 研究结果表明,在这种关联中,炎症,代谢障碍和肠道屏障功能障碍可能起作用.
- 需要进一步的研究来阐明睡眠模式和CRC病变之间的复杂相互作用.
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