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Updated: Jan 12, 2026

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在肝细胞癌中TGF-β1/Smad2/3信号的Ly96介导激活及其基于纳米粒子治疗的潜力

Yixin Zhang1, Sui Zheng1, Xiaoqing Su1

  • 1Department of Ultrasound, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Acta biochimica et biophysica Sinica
|November 4, 2025
PubMed
概括

淋巴细胞抗原96 (LY96) 在肝细胞癌 (HCC) 中过度表达,导致瘤进展和生存率低下. 抑制LY96对新的HCC疗法有很大的前景.

关键词:
在LY96的96年.斯马德2/3 在线观看在TGF-β1中.肝细胞癌是肝细胞癌.免疫性细胞死亡 免疫性细胞死亡

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The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
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