2008年至2017年在韩国对新生儿症状性简单疹病毒感染的多中心研究
Dongsub Kim1,2, Kyung-Ran Kim1,3, Joon-Sik Choi1,4
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Journal of Korean medical science
|November 4, 2025
概括
新生儿简单疹病毒 (HSV) 感染在韩国很少见,但严重,住院婴儿的死亡率为12.5%. 早期诊断和治疗对于新生儿HSV病例的更好的结果至关重要.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 新生儿科学 新生儿科学
背景情况:
- 新生儿简单疹病毒 (HSV) 感染具有重大风险,可能导致严重疾病或死亡.
- 亚洲人群中新生儿HSV感染流行率和特征的数据有限.
- 本研究通过估计韩国新生儿的发病率和评估韩国新生儿的临床特征来解决知识差距.
研究的目的:
- 估计韩国住院婴儿新生儿HSV感染的发生率.
- 描述新生儿HSV感染的临床表现,治疗和结果.
- 提高医疗保健提供者对这种罕见但严重的疾病的认识.
主要方法:
- 韩国12所大学医院进行了一项多中心的回顾性研究.
- 收集了2008年1月至2017年12月期间被诊断出确诊的HSV感染的28天或更年轻的新生儿的数据.
- 审查了患者病历,以收集有关人口统计,临床发现,治疗和结果的信息.
主要成果:
- 新生儿HSV感染的发生率估计为每7,888名住院新生儿中的1例.
- 简单疹病毒1型 (HSV-1) 在62.5%的病例中被发现,HSV-2在37.5%中被发现.
- 中枢神经系统疾病是最常见的表现 (68.8%),30天死亡率为12.5%.
结论:
- 新生儿HSV感染虽然在韩国不常见,但具有相当大的死亡风险.
- 观察到高比例的中枢神经系统参与和发作.
- 提高儿科医生意识对于新生儿HSV感染的及时诊断和管理至关重要.
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