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Updated: Jun 20, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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开发基于纳米粒子的治疗方法,以准肥胖引起的子宫内膜癌的微环境

Laura D Paredes Cuatin1, David Zhang1, Federico Zertuche1

  • 1Department of Biomedical Engineering and Chemical Engineering, The University of Texas at San Antonio, AET 1.328, 1 UTSA Circle, San Antonio, TX 78249 USA.

Cellular and molecular bioengineering
|November 4, 2025
PubMed
概括

这项研究开发了有针对性的纳米颗粒来输送PAI-1 siRNA,有效地使肥胖驱动的子宫内膜癌的癌症因素沉默. 这种新系统在治疗这种常见的妇科恶性瘤方面表现有前途.

关键词:
癌症微环境 癌症微环境这是子宫内膜癌的癌症.在 LCMSN 纳米粒子.肥胖问题 肥胖问题PAI-1是PAI-1的第一个类型.

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...