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基线扩展残疾状况评分和CD8⁺ T细胞水平作为多发性硬化症中残疾进展的危险因素

Pen-Ju Liu¹, Peng Yuan¹, Shui-Ping Liu¹

¹Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, People's Republic of China.

Journal of inflammation research

|November 4, 2025

概括

周围血液中CD8+T细胞水平和基线扩大残疾状态量表 (EDSS) 评分是多发性硬化症 (MS) 残疾进展的关键指标. 这些因素可以帮助监测MS患者的疾病进展.

科学领域:

神经学神经学
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 是一种慢性自身免疫性疾病,影响中枢神经系统.
周围血液T细胞子集的变化与MS的发病和进展有关.
确定可靠的残疾进展生物标志物对于有效的MS管理至关重要.

研究的目的:

为了研究多发性硬化症患者外周血液中的T细胞子集特征.
确定与多发性硬化症中残疾进展相关的独立风险因素.
评估T细胞子集和临床评分作为预后指标的潜力.

主要方法:

从2014年至2024年期间接受治疗的100多名多发性硬化症患者的临床数据的追溯分析.
对外围血液T淋巴细胞子集的流细胞计评估.
根据扩展残疾状况量表 (EDSS) 的得分变化,对残疾进展和非进展组进行分类.
多变量后勤回归用于识别独立的风险因素.

主要成果:

在疾病持续时间,复发频率,发病症状和EDSS分数方面,在进展和非进展组之间观察到显著差异.
在各组之间,T淋巴细胞子集的分布有显著差异.
基线EDSS得分 (p=0.014) 和CD8+T细胞水平 (p=0.042) 被确定为残疾进展的独立风险因素.

结论:

基线EDSS分数和外围血液CD8+T细胞计数是MS中残疾进展的显著独立预测指标.
这些因素可以作为监测疾病进程和指导多发性硬化症治疗策略的宝贵生物标志物.

关键词:

T细胞子集是T细胞的子集.身体残疾就是残疾.多发性硬化症多发性硬化症有关风险因素的风险因素.

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