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儿科MAFLD中LECT2和PEDF升高:诊断性能和代谢相关性

Lanshu Yang^1,2,3, Hongbing Ni⁴, Meiling Deng^1,2

¹Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, People's Republic of China.

Diabetes, metabolic syndrome and obesity : targets and therapy

|November 4, 2025

概括

血清肝激素白细胞细胞衍生化学毒素2 (LECT2) 和色素表皮衍生因子 (PEDF) 在儿科代谢相关脂肪肝疾病 (MAFLD) 中升高. 它们的组合有助于在肥胖儿童中诊断MAFLD.

科学领域:

肝病学肝病学是一种肝病学.
儿科内分泌学儿科内分泌学
生物标志物发现发现

背景情况:

与代谢相关的脂肪肝疾病 (MAFLD) 是儿童日益关注的问题.
对儿科MAFLD的准确诊断工具对于早期干预至关重要.
肝激素,如LECT2和PEDF,与代谢功能障碍和肝损伤有关.

研究的目的:

评估血清LECT2和PEDF对于儿科MAFLD的诊断价值.
评估LECT2和PEDF与代谢和肝损伤指数的相关性.
为了确定LECT2和PEDF的诊断实用性,单独和组合.

主要方法:

一项涉及198名儿童的横截面研究 (78名MAFLD,60名肥胖非MAFLD,60名对照).
血清LECT2和PEDF水平使用标准化试验进行测量.
统计分析包括组比较,相关性分析,ROC曲线分析和后勤回归.

主要成果:

血清LECT2和PEDF水平在不同组中呈现逐步升高 (对照组<肥胖非MAFLD
在MAFLD患者中,LECT2和PEDF水平与BMI,HOMA-IR,ALT和AST有显著的相关性.
组合LECT2/PEDF小组显示,MAFLD与对照组的诊断准确度更高 (AUC=0.849) 和MAFLD与肥胖非MAFLD的中等效用 (AUC=0.712).

结论:

在儿科MAFLD中,LECT2和PEDF升高,并与代谢功能障碍相关.
LECT2/PEDF组合有效地将MAFLD与健康对照区分开来,但对简单肥胖的疗效中等.
LECT2/PEDF小组是肥胖儿童风险分层的一个有希望的工具,识别需要进一步评估MAFLD的儿童.

关键词:

在LECT2中使用LECT2.马夫尔德 (MAFLD) 是一个在PEDF中,PEDF是PEDF.孩子们的孩子们的孩子们的孩子们.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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