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布罗梅林通过SIRT1/PGC-1α和FOXO3a通路的相互作用缓解了大鼠中3 - 基酸诱导的亨廷顿病类症状

Omnia M Nady¹, Salma E Said¹, Sherehan M Ibrahim^2,3

¹Department of Biochemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

BioFactors (Oxford, England)

|November 4, 2025

概括

来自的酶梅林 (bromelain) 显示出对抗亨廷顿病的神经保护性益处.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
药理学药理学是指药理学的学科.

背景情况:

亨廷顿病 (HD) 是一种神经退行性疾病.
在老鼠中,3-尼托罗普罗酸 (3-NP) 模仿了类似HD的症状.
布罗梅林具有抗氧化和抗炎性质.

研究的目的:

为了研究梅林的神经保护作用.
为了评估布罗梅林与3NP诱导的小鼠的疾病类似症状.

主要方法:

鼠被分为四组:对照组,仅使用布罗美林,仅使用3-NP,以及布罗美林+3-NP.
布罗美林 (40毫克/公斤) 和3-NP (10毫克/公斤) 每天在14天内通过腹膜内注射.
评估了分子标记物,氧化应激水平和行为/认知功能.

主要成果:

梅林上调节了条纹性SIRT-1,PGC-1α,TFAM和Nrf2.
它增强了Akt酸化和FOXO3a脱乙化.
布罗梅林降低了氧化应激 (MDA) 和增加了抗氧化剂 (NQO1,TAC,SOD,GSH),改善了运动和认知功能.

结论:

布罗梅林在大鼠中表现出显著的神经保护作用,对3 - NP诱导的HD类症状产生显著的神经保护作用.
它的益处与抗氧化和抗炎途径有关.
布罗梅林是一种潜在的HD治疗候选药物.

关键词:

在PGC-1α/Nrf2中.有关SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的SIRT1/FOXO3a3的 3 - - 尼托罗普罗皮昂酸布罗梅林蛋白 (bromelain) 是一种蛋白质.线粒体生物发生是线粒体生物发生.神经元存活率神经元存活率

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