基于社区药房的注射性阿片类激素治疗:加拿大试点计划的发现
Tamara Mihic1,2, Maria Eugenia Socias1,3, Karen McCrae1
1British Columbia Centre on Substance Use, Vancouver, British Columbia, Canada.
Drug and alcohol review
|November 4, 2025
概括
社区药房注射性阿片类抗体治疗 (iOAT) 试点项目改善了阿片类药物使用障碍患者的治疗结果. 该模型提供了一种新的策略,以扩大那些没有对口服OAT反应的人的治疗机会.
科学领域:
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
- 成 药物 药物 药物 药物
背景情况:
- 对阿片类药物使用障碍 (OUD) 治疗的准入是有限的,特别是对于那些对口服阿片类药物激动剂治疗 (OAT) 无反应的人来说.
- 在加拿大温哥华的一家社区药房设置中实施了一项可注射OAT (iOAT) 试点计划.
- 这份报告详细介绍了该计划的结构,参与者特征,结果和需要改进的领域.
研究的目的:
- 评估基于社区药房的注射性阿片类抗体治疗 (iOAT) 模型的可行性和结果.
- 描述iOAT计划参与者的社会人口统计和治疗经验.
- 确定基于药房的IOAT模型的优势和需要改进的领域.
主要方法:
- 从iOAT计划中的176名参与者的横截面问卷数据的回顾性审查.
- 对参与者报告的结果 (症状,功能,满意度) 的描述性统计分析.
- 对开放式响应的内容分析,以确定程序的优势和需要改进的领域.
主要成果:
- 51名参与者填写了问卷;大多数人先前有过量服用和口服OAT试验.
- 关键结果包括减少非法阿片类药物使用 (76%),减少嗜好 (45%) 和减少非法物质使用 (45%).
- 引用的计划优势是积极的员工互动和药房效率;建议的改进包括药物选择,延长工作时间和支持服务.
结论:
- 基于社区药房的IOAT是一种可行的策略,可以增加获得基于证据的OUD治疗的机会.
- 这种模式对于注射阿片类药物的人来说尤其有益,并且没有成功或更喜欢不使用口服OAT.
- 这些发现突出了基于药房的创新模型的潜力,以解决OUD治疗中的差距.
相关概念视频
Opioid Analgesics: Synthetic and Semisynthetic Opioids
906
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
906
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
244
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
244
Opioid Analgesics: Morphine and Other Natural Cogeners
837
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
837
Drug Delivery: Miscellaneous Routes
705
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
705
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
225
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
225
Opioid Receptors: Overview
4.0K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.0K


