献血者西尼罗河病毒查发现西班牙有三个本土的乌苏图病毒感染病例
Teresa Jimenez-Marco1,2, Maria Piron3,4,5, Gabriela Capllonch-Amer1
1Fundació Banc de Sang i Teixits de les Illes Balears, Palma de Mallorca, Spain.
Transfusion
|November 4, 2025
概括
在西尼罗河病毒 (WNV) 季节,在西尼罗河病毒 (WNV) 季节的西班牙献血者中发现了三例乌苏图病毒 (USUV) 感染. 这凸显了需要提高认识的必要性,因为在例行查期间,USUV可能会被误认为是WNV.
科学领域:
- 病毒学 病毒学
- 公共卫生 公共卫生
- 输血医学 输血医学
背景情况:
- 西尼罗河病毒 (WNV) 在欧洲的传播需要在血液银行进行WNV核酸测试 (NAT) 查.
- 乌苏图病毒 (USUV) 是WNV的亲属,在WNV诊断测试中表现出交叉反应性.
研究的目的:
- 在西班牙2024年WNV季节调查西班牙献血者中USUV感染的存在.
- 评估USUV可能导致假阳性WNV查结果的可能性.
主要方法:
- 使用商业NAT测试对来自巴莱尔群岛和加泰罗尼亚的95,357份献血进行WNV查.
- 通过血清学测试,USUV和WNV特定的PCR,RNA测序和中和测试来确认阳性结果.
主要成果:
- 在献血者中检测到三个本土的USUV感染.
- 其中两个USUV感染被确定为非洲3系.
- 总体检测率为31,786次捐献中的1次.
结论:
- 在西班牙,USUV感染是一个新兴的动物性疾病威胁,影响了输血安全.
- 卫生当局必须将USUV视为阳性WNV查结果的潜在原因.
- 由于与WNV诊断的交叉反应性,USUV的报告不足可能会发生.
相关概念视频
Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...


