乳球菌和热球菌的宿主相互作用支持它们适应人类肠道微生物群
Gabriele Andrea Lugli1,2, Chiara Argentini1, Chiara Tarracchini1
1Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy.
Applied and environmental microbiology
|November 4, 2025
概括
乳酸细菌 (LAB) 像乳球菌 (Lactococcus lactis) 和热菌 (Streptococcus thermophilus) 在人类肠道中很常见. 研究人员确定了特定的菌株,PRL2024和PRL2025,表明它们可以壮成长和代谢营养素,为功能性食品提供潜力.
科学领域:
- 微生物学 微生物学
- 肠道微生物组研究研究
- 食品科学 食品科学 食品科学
背景情况:
- 乳酸细菌 (LAB) 对肠道健康和平衡至关重要.
- 对于LAB与宿主和肠道共生物相互作用的了解有限.
- 一万名健康成年人的肠道微生物群数据揭示了常见的食物细菌:乳糖菌和热菌.
研究的目的:
- 识别和功能性地描述适应人类的L. lactis和S. thermophilus的参考菌株.
- 研究这些菌株的生态弹性和代谢多功能性.
- 评估它们作为向微生物群的功能性食品的潜力.
主要方法:
- 在分析以确定参考菌株 (L. lactis的PRL2024,S. thermophilus的PRL2025).
- 在体外实验以评估在胃肠道中生存,相互作用和碳来源利用.
- 乳糖代谢的具体研究,包括银河糖的利用和酸的产生.
主要成果:
- L. lactis PRL2024和S. thermophilus PRL2025被确定为人类肠道内的游牧细菌.
- 这两种菌株都表现出人类胃肠道内的生态适应和生存能力.
- L. lactis PRL2024完全利用了银河糖,而酸的产量较低,而S. thermophilus PRL2025尽管酸的产量很高,但银河糖代谢不完全.
结论:
- PRL2024和PRL2025为未来的体内研究提供了有价值的人类适应基准菌株.
- 它们的弹性,代谢多功能性和相互作用潜力将它们定位为功能性食物的有希望的候选者.
- 了解它们的特定代谢途径,如银河糖利用,是有针对性的微生物群调节的关键.
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