中性粒细胞C反应蛋白指数作为一种新的急性胰腺炎预后工具,用于资源有限的环境
Tien Manh Huynh1,2, Thinh Ong3, Duy Thanh Tran4
1Department of Internal Medicine, School of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
International journal of surgery (London, England)
|November 4, 2025
概括
中性粒细胞×C反应蛋白指数 (NCI) 有效地预测严重急性胰腺炎和死亡率. 这种简单的生物标志物有助于早期风险分层,特别是在资源有限的环境中.
科学领域:
- 胃肠病学和肝病学
- 生物标志物发现发现
- 临床诊断 临床诊断 临床诊断
背景情况:
- 早期风险分层对于急性胰腺炎 (AP) 管理至关重要,特别是在资源有限的环境中.
- 中性粒细胞×C反应蛋白指数 (NCI) 被提出作为预测AP严重性的新生物标志物.
- 这项研究旨在评估NCI在识别严重急性胰腺炎 (SAP) 和住院死亡率方面的有效性.
研究的目的:
- 评估中性粒细胞×C反应蛋白指数 (NCI) 作为严重急性胰腺炎 (SAP) 的预测生物标志物.
- 评估NCI预测急性胰腺炎患者住院死亡率的能力.
- 将NCI的性能与现有的评分系统和其他生物标志物组合进行比较.
主要方法:
- 一项前性队列研究招募了越南257名成年AP患者.
- 为了计算NCI,在24小时内测量了中性粒细胞和C反应蛋白 (CRP) 水平.
- 使用曲线下面面积 (AUC) 分析评估NCI性能,并与BISAP,CLR,NLR和NCLR进行比较.
主要成果:
- 在培训和验证队列中,NCI显示了SAP (AUC 0.853-0.897) 和住院死亡率 (AUC 0.824-0.902) 的强大预测性能.
- 在预测SAP和死亡率方面,NCI的表现优于CLR和NLR,与NCLR和BISAP的表现相当.
- 观察到NCI和SAP风险之间存在线性关系,并确定了SAP和死亡率预测的最佳切断值.
结论:
- 中性粒细胞×C反应蛋白指数 (NCI) 是一种简单,可访问和有效的生物标志物,用于SAP和住院死亡率的早期风险分层.
- 在资源有限的环境中,NCI的实用性尤其显著,促进了及时的患者分拣和管理.
- 用于NCI计算的常规血液测试支持其在急性胰腺炎患者的临床环境中的实际应用.
相关概念视频
Acute Pancreatitis II: Clinical Manifestations and Management
723
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
723
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
529
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
529
Chronic Pancreatitis II: Collaborative Care
306
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
306
Acute Pancreatitis I: Introduction
1.1K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.1K
Acute Pyelonephritis II: Diagnostic Studies and Management
301
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
301


