最近绝经后妇女中中央脂肪和认知领域功能之间的关联:克罗诺斯早期雌激素预防研究KEEPS-Cog子研究的分析
Taryn T James1, N Maritza Dowling2, Carola Ferrer Simó1
1University of Wisconsin-Madison, Madison, WI.
概括
中部脂肪,以腰部和部的比例来衡量,与早期绝经后妇女的认知能力下降有关. 在KEEPS-Cog研究中,更年期激素治疗没有改变这一关联.
科学领域:
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 中枢脂肪是心血管疾病和认知障碍的独立风险因素.
- 早期绝经后的女性是调查认知健康和潜在干预措施的关键窗口.
- 克罗诺斯早期雌激素预防研究 (KEEPS) 评估了更年期激素治疗 (MHT) 在健康的,早期更年期后妇女.
研究的目的:
- 检查早期绝经后妇女中中央脂肪和认知功能之间的关系.
- 确定更年期激素治疗 (MHT) 是否改变了中心脂肪和认知功能之间的关联.
- 重新分析KEEPS-认知和情感 (KEEPS-Cog) 子研究的数据.
主要方法:
- 利用了727名女性 (42-58岁) 的数据,这些女性被随机分配给口服结合性马类雌激素 (o-CEE),透皮17-β-雌激醇 (t-E2) 或安慰剂.
- 排除了具有显著心脏代谢风险因素的参与者.
- 在多个时间点评估四个领域 (记忆,注意力,执行功能,语言) 的认知功能.
- 测量腰比 (WHR) 作为中心脂肪的指标,并使用线性潜伏生长模型.
主要成果:
- 较高的基线WHR与基线所有领域的认知表现较差显著相关.
- 在48个月的研究期间,增加WHR预测视觉注意力和执行功能的下降.
- 在MHT (o-CEE或t-E2) 和WHR之间没有发现对认知结果的显著相互作用效应.
结论:
- 中枢脂肪率是早期绝经后妇女特异性认知衰退的重要危险因素.
- 在这个人群中,认知健康应该是重点关注的,无论他们的基线心血管风险如何.
- 在这个队列中,MHT没有减轻中心脂肪的负面认知关联.
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