喉喉逆流性疾病:一项试点研究,使用一种新的多组分药物
Andrea Nacci1, Alberto Galli1, Luca Bastiani2
1ENT Audiology and Phoniatric Unit, University of Pisa, Pisa, Italy.
一种新的多元组件设备显著改善了喉回流病 (LPRD) 的症状和迹象. 早期干预显示出更大的益处,支持其作为非酸抑制治疗选择的使用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喉回流性疾病 (LPRD) 在管理方面提出了挑战.
- 评估新型治疗设备对于LPRD治疗至关重要.
- 评估了一种含有Gingigel Pro®,基酸盐,Tamarindus indica,酸和植物提取物的多元器件设备.
研究的目的:
- 评估LPRD新型多组件医疗器械的有效性和安全性.
- 评估主观反流症状和客观喉镜症状的改善情况.
- 根据症状持续时间来探索治疗结果.
主要方法:
- 对22名成年LPRD患者进行前性观察性研究.
- 治疗包括设备 (2个月每天两次使用一根棒) 和咨询.
- 结果指标包括修订后流症症状指数 (R-RSI),语音障碍指数-10 (VHI-10) 和后流症标志评估 (RSA).
主要成果:
- 在治疗后的R-RSI,VHI-10和RSA得分中观察到显著的改善 (P<0.0001).
- 病理性R-RSI得分从100%降至9.1%;病理性RSA得分从100%降至59.1%.
- 早期症状发作 (0-4个月) 与更大的症状和迹象改善相关.
结论:
- 这种多元组件装置在治疗LPRD方面表现出有效性和安全性.
- 在LPRD患者的早期干预产生了卓越的治疗效益.
- 这些发现支持对LPRD的非抑制酸剂的使用,需要进一步研究.
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