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在双相情绪障碍患者中,基于全血细胞计的炎症指数和症状严重程度:基于结构方程建模的分析
Daniele Cavaleri1, Cristina Crocamo1, Ilaria Riboldi1
1School of Medicine and Surgery, University of Milano-Bicocca, via Cadore 48, 20900, Monza, Italy.
European archives of psychiatry and clinical neuroscience
|November 4, 2025
概括
基于完整血清 (CBC) 的炎症指数,包括中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR),显示出与躁狂和抑郁症状严重程度的明显关联. 这些可访问的标记物可能有助于监测BD患者的情绪状态.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 双极性障碍 (BD) 可能与免疫炎症失调有关.
- 基于全血细胞计 (CBC) 的炎症指数,如中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR) 和血小板与淋巴细胞的比率 (PLR),正在成为精神疾病的经济有效标志物.
研究的目的:
- 调查NLR,MLR和PLR与BD患者躁狂和抑郁症状严重程度之间的关系.
- 检查这些基于CBC的比率与临床变量之间的相互作用.
主要方法:
- 结构方程建模 (SEM) 用于分析175名BD住院患者的数据.
- 基于CBC的比率是从血液样本中计算出来的,并与通过年轻躁狂评分表 (YMRS) 和蒙哥马利-奥斯伯格抑郁评分表 (MADRS) 评估的症状严重程度相关联.
- 分析考虑了年龄,性别,BMI,物质使用障碍和精神药物.
主要成果:
- 与抑郁症相比,在躁狂发作中,MLR显著高于抑郁症发作.
- SEM揭示了更高的躁狂症状严重程度 (YMRS) 与增加的NLR和MLR有关,并降低了PLR.
- 抑郁症症状严重程度增加 (MADRS) 与MLR降低和PLR增加有关.
结论:
- 在BD的躁狂和抑郁发作中,NLR,MLR和PLR表现出与症状严重性的差异关联,这表明复杂的免疫-炎症参与.
- 这些基于CBC的比率可以作为监测双相情绪障碍情绪状态严重性的可访问指标.
- 需要进一步的研究来探索这些炎症指数在BD管理中的临床实用性.
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