与健康同龄人相比,在原发性纤维动力障碍症中对心肺和野外运动测试的生理反应
Aslihan Cakmak-Onal1, Elif Kocaaga2, Hazal Sonbahar-Ulu3
1Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Türkiye. aslihancakmak90@gmail.com.
European journal of applied physiology
|November 4, 2025
概括
患有原发性纤维动力障碍 (PCD) 的儿童对心肺运动测试 (CPET) 和增量穿步行测试 (ISWT) 的生理反应相似,但在6分钟步行测试 (6MWT) 中的反应较低. 在PCD中,CPET更有效地识别呼吸系统低效率.
科学领域:
- 儿科肺病学 儿科肺病学
- 运动生理学 运动生理学
- 罕见疾病 罕见疾病
背景情况:
- 初级状动力障碍 (PCD) 是一种影响状动力的遗传疾病,导致状动力清除受损和呼吸系统问题.
- 与健康同龄人 (HP) 相比,患有PCD (cwPCD) 的儿童可能对运动有不同的生理反应.
研究的目的:
- 为了比较心肺运动测试 (CPET),增量穿步行测试 (ISWT) 和cwPCD和HP的6分钟步行测试 (6MWT) 的生理反应.
- 研究cwPCD中临床参数和运动反应之间的关联.
主要方法:
- 23个cwPCD和23个HP接受了肺功能测试和呼吸肌肉强度评估.
- 参与者进行了CPET,ISWT和6MWT,并监测了心率 (HR),血压 (BP),氧和度 (SpO2) 和感知到的劳动力 (Borg尺度).
- 运动前后的评估包括SPO2,HR,BP和Borg尺度对呼吸障碍和疲劳的评级.
主要成果:
- CPET和ISWT显示,cwPCD和HP (p > 0.05) 之间的HR,SPO2,缩BP和感知劳力的反应相似.
- 与HP相比,6MWT在cwPCD中引起了较低的生理反应 (p <0.05).
- 与HP相比,cwPCD在无氧值时表现出较低的峰值氧气吸收 (峰值VO2),相对峰值VO2和心率变化 (ΔHR),以及较高的分钟通风/二氧化碳产生 (VE/VCO2) (p <0.05).
- 在两组中,峰值VO2与ISWT距离 (ISWD) 和6MWT距离 (6MWD) 相相关 (p <0.05).
- 回归模型根据6MWD (R2 = 0.269) 和ISWD (R2 = 0.329) 预测了相对峰值VO2.
结论:
- CPET和ISWT产生了可比的生理反应,而6MWT在cWPCD中显示了减少的反应,尽管它仍然是一个有价值的措施,因为它与峰值VO2有关.
- cwPCD显示呼吸器 (VE) 控制发生变化,运动期间CO2提前增加,呼吸器效率较低,慢性损伤.
- CPET比现场测试更有效,用于识别患有PCD的儿童的呼吸系统低效和慢性损伤.
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