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口腔/肠道微生物群和肺癌之间的因果关系:一个双样本的门德尔随机化研究

Zi-Jian Huang¹, Lv Wu¹, Ying-Long Peng^1,2

¹Guangdong Lung Cancer Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510,080, China.

Discover oncology

|November 4, 2025

概括

特定的口腔和肠道细菌会影响肺癌风险. 一些细菌可能会防止肺癌,而另一些则会增加风险,为诊断提供潜在的点.

科学领域:

微生物组研究的研究.
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

越来越多的证据将微生物群组成与包括癌症在内的各种疾病联系在一起.
口腔和肠道微生物群在肺癌发展中的特定作用需要进一步阐明.

研究的目的:

调查口腔和肠道微生物群与肺癌风险之间的因果关系.
确定可能影响个体对肺癌易感性的特定微生物种群.

主要方法:

在全基因组关联研究 (GWAS) 数据上利用两样本的门德尔随机化 (MR) 分析.
检查了口腔微生物群 (2984名健康人群) 和肠道微生物群 (2002名健康人群) 作为暴露物.
分析了来自212,453名个人的肺癌GWAS数据,采用逆变量加权 (IVW) 方法.

主要成果:

口腔属Pauljensenia,Capnocytophaga和Aggregatibacter显示出对肺癌的潜在保护作用.
肺癌的风险增加与口服属Granulicatella,Streptococcus,Saccharimonadaceae TM7x和Neisseria有关. 这种类型的肺癌的风险增加与口服属Granulicatella,Streptococcus,Saccharimonadaceae TM7x和Neisseria有关. 这种类型的肺癌的风险增加与口服属Granulicatella,Streptococcus,Saccharimonadaceae TM7x和Neisseria有关.
肠道细菌Enterococcus faecalis与肺癌风险增加有积极联系.

结论:

研究结果表明,特定的口腔和肠道微生物群落与肺癌之间存在潜在的因果关系.
已识别的微生物候选者可能成为肺癌诊断策略的新目标.
进一步的研究可以探索针对已识别的微生物群的治疗干预措施.

关键词:

我们的肠道微生物群.肺癌是一种肺癌.门德尔的随机化口腔的微生物群.单个核酸的多态性.

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