减少在产前肺栓塞诊断中先进成像的策略
David R Vinson1,2,3,4, Madeline J Somers2, Lara Zekar4
1The Permanente Medical Group, Pleasanton, California.
D-二聚体检测是诊断怀孕患者肺栓塞 (PE) 的有效和安全策略,减少了对高级成像的需求. 超声波效率较低,但可以通过症状驱动的使用来改善.
科学领域:
- 产科和妇科 产科和妇科
- 心脏病学 心脏病学
- 放射学 放射学是指放射学
背景情况:
- 在怀孕期间进行肺栓塞 (PE) 的高级成像具有辐射暴露和过度诊断等风险.
- D-二次测试和压缩超声波可以帮助分别排除PE和诊断深静脉血栓症 (DVT),从而减少对高级成像的需求.
- 这些诊断策略在社区环境中用于产前PE的使用情况尚不清楚.
研究的目的:
- 评估使用和诊断效率的D-二分体测试和超声波用于产前PE.
- 确定需要测试的数量 (NNT),以避免在孕妇中进行先进的PE成像.
主要方法:
- 美国21家社区医院的回顾性队列研究 (2021年10月 - 2023年3月).
- 包括怀孕患者怀疑PE接受了D-二次体测试,压缩超声波或高级成像.
- 通过准波桑回归分析了先进的成像,NNT和影响测试使用的因素的避免.
主要成果:
- 在720次接触中,72.8%使用了D-二聚体测试. 低D-二次数值 (<0.5 mg/L) 避免了96.1% (NNT=2.3) 的高级成像.
- 在45.8%的 (NNT=2.3) 中间D-二次数值 (0.5到<1.0 mg/L) 避免了高级成像.
- 31.8%的患者进行了压缩超声波;1.3%的患者被诊断为DVT,只有2例避免了高级成像 (NNT=115). 症状驱动的超声波显示出更高的产量.
结论:
- D-二聚体检测是产前PE诊断的有效和安全方法,具有更广泛应用的潜力.
- 在这种情况下,超声波的效率很低,这表明以症状为导向的方法可以提高它的效用.
- 优化D-模和超声波的使用可以改善产前PE诊断,减少对先进成像的依赖.
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