多部位和特定部位慢性疼痛之间的关联,止痛药的使用,代谢-蛋白质基因特征,以及糖尿病中慢性病的发生
Sisi Yang1, Yiwei Zhang2, Yu Huang3
1Sisi Yang, M.D.: Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; National Clinical Research Center for Kidney Disease, Guangzhou, China; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Guangzhou, China; Guangdong Provincial Institute of Nephrology, Guangzhou, China; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, China.
Anesthesiology
|November 4, 2025
概括
多部位慢性疼痛和阿片类药物使用增加了糖尿病患者慢性病 (CKD) 的风险. 这些发现强调需要谨慎的疼痛管理,以保护糖尿病患者的脏健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 疼痛医学 医学 疼痛医学
背景情况:
- 慢性疼痛在糖尿病中很常见,但其与慢性病 (CKD) 风险的联系尚不清楚.
- 了解这种关联对于管理糖尿病并发症至关重要.
研究的目的:
- 调查慢性疼痛 (多部位和特定部位) 和止痛药使用与糖尿病患者中CKD风险之间的关系.
- 识别与慢性疼痛和CKD风险相关的代谢和蛋白质组特征.
主要方法:
- 分析了来自20208名糖尿病患者的英国生物库数据.
- 使用多变量考克斯回归来评估慢性疼痛,止痛药使用 (ibuprofen,paracetamol,阿片类药物) 和发生的CKD之间的关联.
- 集成的多组数据 (代谢物,蛋白质) 探索生物途径.
主要成果:
- 慢性疼痛与18%的CKD风险增加相关;多部位疼痛显示剂量依赖的增加.
- 部/肩膀,背部,部,膝盖和胃/腹部区域的疼痛与更高的CKD风险有显著的关联.
- 慢性疼痛患者的阿片类药物使用与CKD风险增加有关,与布洛芬或类药物不同.
- 增加的染色素-A,增加的糖蛋白乙和减少的欧米茄-3脂肪酸被确定为生物标志物.
- 瘤亡因子 (TNF) 和表皮生长因子受体 (EGFR) 成为疼痛-CKD关联的关键节点.
结论:
- 多部位慢性疼痛和阿片类药物使用与糖尿病中CKD风险增加有关.
- 代谢和蛋白质组数据支持这些关联.
- 强调了意识疼痛管理策略在糖尿病护理中的重要性.
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