道化纳米管介导干细胞免疫调节功能障碍促进脂肪炎症和GDM中的胰岛素抵抗
Bingnan Chen1, Xuyang Chen2, Jianxin Li2
1Department of Obstetrics and Gynecology, Chongqing Key Laboratory of Maternal and Fetal Medicine / Joint International Research Laboratory of Reproduction & Development, Ministry of Education / The Innovation and Talent Recruitment Base of Maternal-Fetal Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Cell reports
|November 4, 2025
概括
脂质衍生干细胞 (ADSCs) 通过道纳米管 (TNTs) 与免疫细胞通信,以传输线粒体,保持代谢平衡. 这种ADSC疗法通过恢复免疫细胞功能来治疗妊娠糖尿病 (GDM) 是有前途的.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 干细胞生物学 干细胞生物学
- 孕产妇与胎儿医学 孕产妇与胎儿医学
背景情况:
- 脂肪衍生干细胞 (ADSC) 是一种潜在的疗法,但它们的免疫相互作用尚不清楚.
- 脂肪组织中免疫细胞的代谢调节至关重要,特别是在怀孕期间.
研究的目的:
- 为了研究脂肪组织中ADSC-巨细胞通信的机制.
- 探索这种相互作用在怀孕期间维持代谢平衡中的作用.
- 评估基于ADSC的孕期糖尿病治疗方法.
主要方法:
- 孕期糖尿病 (GDM) 的小鼠模型.
- 活细胞成像和扫描电子显微镜.
- 多个omics分析和WNT5A-RhoA-ROCK1轴的调查.
主要成果:
- ADSCs通过道纳米管 (TNTs) 将线粒体转移到脂肪组织巨细胞 (ATM).
- 这种由WNT5A-RhoA-ROCK1调节的线粒体转移维持了ATM的代谢适应性.
- 在代谢应激下受损的转移导致GDM的ATM炎症和胰岛素抵抗.
- 在现场ADSC的使用恢复了线粒体转移,改善了GDM代谢参数.
结论:
- 通过TNT介导的线粒体共享是一种关键的干细胞-免疫相互作用机制.
- ADSC疗法可以重编程免疫细胞代谢,为GDM提供潜在的治疗方法.
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